维生素D可能不会改善脂质水平:一项连续临床实验室数据研究
Manish P Ponda1, Xiaohua Huang, Mouneer A Odeh
1The Rockefeller University, New York, NY, USA.
Circulation
|June 22, 2012
概括
维生素D缺乏与血脂样本不良有关. 然而,纠正这种缺陷可能不会显著改善胆固醇或甘油三水平,因此需要进一步进行干预试验.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 临床化学 临床化学
背景情况:
- 维生素D缺乏是常见的,并与失脂症和心血管疾病有关.
- 纠正维生素D缺乏对血液脂质的影响尚不清楚.
研究的目的:
- 调查25-基维生素D水平与脂质概况之间的关联.
- 为了确定纠正维生素D缺乏症是否会影响脂质度.
主要方法:
- 超过400万患者实验室结果的横截面分析.
- 对维生素D缺乏症患者进行回顾性队列研究,检查维生素D和脂质水平的变化.
主要成果:
- 最佳的维生素D水平 (≥30 ng/mL) 与较低的总胆固醇,LDL胆固醇和甘油三和较高的HDL胆固醇相比,与缺乏 (<20 ng/mL) 相关.
- 从缺乏维生素D水平提高到最佳水平与总胆固醇和高密度胆固醇的小幅增加有关,但LDL胆固醇或甘油三的显著变化没有.
结论:
- 虽然维生素D缺乏与不利的脂质样本相关,但在纠正后脂质的临床改善可能有限.
- 需要进行干预试验来确认维生素D补充对脂质度的影响.
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