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Updated: May 21, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach
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Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

在乳腺癌亚型中对突变和转位的序列分析

Shantanu Banerji1, Kristian Cibulskis, Claudia Rangel-Escareno

  • 1The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.

Nature
|June 23, 2012
PubMed
概括

这项研究对乳腺癌基因组进行了测序,确定了CBFB和RUNX1.1中的新突变. 在三阴性乳腺癌中发现了一种新的MAGI3-AKT3融合,激活AKT激酶.

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gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

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Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...