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药物修饰的HLA-谱引发的免疫自我反应

Patricia T Illing1, Julian P Vivian, Nadine L Dudek

  • 1Department of Microbiology & Immunology, University of Melbourne, Parkville, Victoria 3010, Australia.

Nature
|June 23, 2012
PubMed
概括

像HLA-B*57:01这样的特定人类白细胞抗原 (HLA) 基因组可以与阿巴卡维尔等药物结合,改变免疫系统的自我识别并引起过敏反应. 这种机制解释了与HLA相关的药物反应,并告知了药物基因组学.

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