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Updated: May 21, 2026

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
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A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

稳定结构切换信号RNA吸收体通过被困在固相测定中的sol-gel衍生材料中

Carmen Carrasquilla1, Pui Sai Lau, Yingfu Li

  • 1Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada, L8S 4M1.

Journal of the American Chemical Society
|June 26, 2012
PubMed
概括

现在可以在固体表面使用sol-gel捕获来稳定RNA吸附体,从而实现了新的生物传感器应用. 这种方法可以保护亚体免受降解,并保持它们的信号传输能力,以可靠地检测.

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RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...