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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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p53打开了线粒体的透性过渡孔,从而触发了死

Angelina V Vaseva1, Natalie D Marchenko, Kyungmin Ji

  • 1Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA.

Cell
|June 26, 2012
PubMed
概括

这项研究揭示了p53蛋白在氧化应激过程中通过与线粒体中的环素D相互作用触发死亡. 阻止这种相互作用可以防止中风,突出显示出缺血的新治疗点.

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