通过异酸盐进行单RAFT/"点击"化学:高效合成α端功能化聚合物
Guillaume Gody1, Christian Rossner, John Moraes
1Key Centre for Polymers & Colloids, School of Chemistry, The University of Sydney, New South Wales 2006, Sydney, Australia.
Journal of the American Chemical Society
|June 27, 2012
概括
一种新的单方法使用碳酸链转移剂 (CTA) 在可逆添加-碎片化链转移 (RAFT) 聚合中制备α-功能性聚合物. 这种方法使得具有反应性异酸盐末端组的聚合物能够得到控制的合成.
科学领域:
- 聚合物化学 聚合物化学
- 有机合成 有机合成
背景情况:
- 合成具有特定终端组功能的聚合物,如异酸盐,由于这些组的反应性,具有挑战性.
- 现有的制造异酸盐终结聚合物的方法通常涉及多个步骤和困难的处理程序.
研究的目的:
- 开发一种精简的,单一的方法来制备具有受控分子量和异酸盐末组的α-功能性聚合物.
- 引入一种多功能碳酸链转移剂 (CTA),用于同时聚合和异酸盐"点击"功能.
主要方法:
- 使用可逆添加碎片化链转移 (RAFT) 聚合.
- 开发了一种新型的碳酸链转移剂 (CTA) 前体.
- 在RAFT聚合过程中CTA在现场Curtius重排,以产生α-异酸盐的功能.
- 证明了对各种单体的聚合的控制,包括 (甲基) 烯酸盐,烯胺和 styrenes.
主要成果:
- 实现了对各种单体的良好控制的聚合,产生具有可预测分子量 (M(n) = 2-30 kDa) 和低分散度 (Đ = 1.16-1.38) 的聚合物.
- 在单个合成步骤中成功生成α-异酸改性聚合物.
- 通过RAFT聚合/异酸盐"点击"程序验证了碳酸CTA作为一种通用平台,用于通过RAFT聚合/异酸盐"点击"程序创建α端功能化聚合物.
结论:
- 开发的单RAFT聚合/异酸"点击"反应为合成α-异酸功能聚合物提供了一种高效和多功能策略.
- 这种方法克服了与合成和处理反应性异酸盐中间体相关的局限性,在聚合物合成中取得了重大进展.
- 碳酸CTA作为一个强大的平台,通过简化合成路径创建广泛的α端功能化聚合物.
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