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一个MDM2-p53抑制剂AM-8553的快速合成

Brian S Lucas1, Benjamin Fisher, Lawrence R McGee

  • 1Department of Medicinal Chemistry, Amgen, Inc., S. San Francisco, California 94080, United States. blucas@amgen.com

Journal of the American Chemical Society
|June 28, 2012
PubMed
概括

复杂的MDM2/p53抑制剂AM-8553的新合成途径显著改善了产量. 这种优化过程利用先进的化学反应来高效地开发药物.

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