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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
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一个表观遗传沉默通路控制T助手2细胞谱系的承诺

Rhys S Allan1, Elina Zueva, Florence Cammas

  • 1Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France.

Nature
|July 6, 2012
PubMed
概括

SUV39H1H3K9me3HP1α通路通过沉默T辅助1 (TH1) 基因来维持T辅助2 (TH2) 细胞的稳定性. 这种途径的损失促进TH1反应,并加剧过敏性喘.

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