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Updated: May 20, 2026

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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在复合系统中T细胞受体触发的生物物理机制

John R James1, Ronald D Vale

  • 1Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, USA.

Nature
|July 6, 2012
PubMed
概括

T细胞受体 (TCR) 信号由结MHC (pMHC) 相互作用启动. 这项研究揭示了TCR信号需要细胞膜中酶和酸酶的空间分离,这是一种适用于癌症免疫治疗的机制.

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