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TNF受体1基因风险反映了多发性硬化症中抗TNF治疗的结果

Adam P Gregory1, Calliope A Dendrou2, Kathrine E Attfield2

  • 1MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

Nature
|July 18, 2012
PubMed
概括

全基因组关联研究确定了一个与多发性硬化症 (MS) 相关的遗传变异,rs1800693. 这种TNFRSF1A基因的变异产生了瘤亡因子受体1 (TNFR1) 的可溶性形式,模仿其他自身免疫性疾病中使用的TNF阻断药物.

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