艾滋病毒感染患者的动脉炎症
Sharath Subramanian1, Ahmed Tawakol, Tricia H Burdo
1MR-PET-CT Program and Department of Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
JAMA
|July 24, 2012
概括
患有人类免疫缺陷病毒 (HIV) 的患者表现出动脉炎症的增加,即使疾病受到控制,传统风险因素较低. 这种炎症与单细胞和巨细胞激活标记物有关.
科学领域:
- 心血管研究的心血管研究.
- 免疫学 免疫学 免疫学
- 放射学 放射学是一门学科.
背景情况:
- 人类免疫缺陷病毒 (HIV) 感染的个体心血管疾病 (CVD) 风险较高.
- 导致这种心血管疾病风险增加的确切机制尚不清楚.
- 单细胞和巨细胞激活,可溶性CD163 (sCD163) 表示,可能起到作用.
研究的目的:
- 为了评估艾滋病毒患者的动脉壁炎症,使用18fluorine-2-deoxy-D-glucose正子发射断层扫描 (18F-FDG-PET).
- 将动脉炎症与传统和非传统的心血管风险标志物相关联,包括sCD163.
- 将艾滋病毒患者的动脉炎症与非艾滋病毒控制组进行比较.
主要方法:
- 马萨诸塞州总医院的一项涉及81名参与者 (27名艾滋病病毒感染者,54名对照者) 的横截面研究.
- 心脏18F-FDG-PET通过对主动脉的目标与背景比率 (TBR) 评估了动脉炎症.
- 冠状动脉计算机断层扫描评估了冠状动脉;与年龄/性别/弗雷明汉风险评分 (FRS) 匹配和动脉样硬化对照进行了比较.
主要成果:
- 艾滋病毒参与者有良好的控制艾滋病毒疾病和低平均FRS,类似于FRS匹配的对照.
- 与FRS匹配的对照组相比,艾滋病毒患者的大动脉TBR (动脉炎症) 显着更高 (P < .001).
- 艾滋病毒患者的大动脉TBR与sCD163水平 (P = .04) 相关,但不是C反应蛋白或D-dimer.
结论:
- 与心脏风险概况相似的非感染者相比,感染艾滋病毒的个体表现出动脉炎症的增加.
- 这种增强的炎症与单细胞和巨细胞激活标记物有关.
- 研究结果表明,艾滋病毒,免疫激活和亚临床血管炎症之间存在联系.
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