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相关概念视频

Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Riboswitches01:56

Riboswitches

Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
Nucleosome Remodeling02:54

Nucleosome Remodeling

Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...

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相关实验视频

Updated: May 20, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

一个机械电子DNA开关.

Jason M Thomas1, Hua-Zhong Yu, Dipankar Sen

  • 1Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.

Journal of the American Chemical Society
|July 28, 2012
PubMed
概括
此摘要是机器生成的。

我们开发了一种新的DNA纳米机器,它使用离子 (Hg2+) 来控制机械运动和DNA电荷传输. 这种用激活的DNA开关将物理运动与电子信号联系起来,使新的纳米设备监控能力成为可能.

更多相关视频

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

相关实验视频

Last Updated: May 20, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

科学领域:

  • * 纳米技术的使用
  • * 分子生物学 * 分子生物学
  • * 生物物理 生物物理

背景情况:

  • *DNA纳米机器为纳米尺度设备提供了潜力.
  • *控制DNA纳米结构中的机械运动和电子特性是一个关键的挑战.

研究的目的:

  • * 设计一种DNA纳米机器,将机械运动结合起来,使用离子来充电运输.
  • *为了展示基于DNA的机械电子开关,可以通过电子方式监控.

主要方法:

  • * 构建一个带有结域的三向螺旋结DNA纳米机器.
  • * 化学足迹和关氨酸氧化试验用于监测电荷运输.
  • * 福斯特共振能量转移 (FRET) 来追踪机械运动.

主要成果:

  • *与T-T不匹配结合的 (Hg2+) 形成了T-Hg2+-T基对,显著增强了电荷传输.
  • *Hg2+结合/解离与DNA茎的机械运动直接相关.
  • * 增强的电荷传输与茎从曲移动到线性,同轴堆叠的形状有关.

结论:

  • *创造了一种新的DNA纳米机器,可以将结合转化为机械运动和改变电荷传输.
  • *这种激活的DNA开关为通过电子测量监测纳米设备机械工作提供了一个范例.