运动训练对慢性心力衰竭患者抑郁症状的影响:HF-ACTION随机试验
James A Blumenthal1, Michael A Babyak, Christopher O'Connor
1Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, PO Box 3119, Durham, NC 27710, USA. blume003@mc.duke.edu
JAMA
|August 2, 2012
概括
与常规护理相比,有氧运动训练在心力衰竭患者中适度减少了抑郁症状. 这种干预也显示出减少死亡或住院的趋势,尽管临床意义需要进一步研究.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 运动科学 运动科学
背景情况:
- 抑郁症在心力衰竭患者中很普遍,增加了不良结果.
- 有氧运动显示出降低抑郁症状的潜力.
- 有限的研究存在于运动对心力衰竭中的抑郁的影响.
研究的目的:
- 评估运动训练在改善心力衰竭患者抑郁症状方面的有效性.
- 为了比较运动训练与心力衰竭中抑郁症管理的常规护理.
主要方法:
- 一个多中心随机对照试验,包括2322名稳定的心力衰竭患者.
- 患者被随机分配到受监督的有氧运动或以常规指南为基础的护理.
- 主要结局包括3个月和12个月的死亡/住院和贝克抑郁症目录II (BDI-II) 评分.
主要成果:
- 与常规护理相比,有氧运动在3个月和12个月后导致BDI-II得分明显降低.
- 运动组显示了减少死亡或住院的趋势 (HR,0.89;P = .03).
- 在基线时,28%的参与者有临床显著的抑郁症状 (BDI-II ≥14).
结论:
- 运动训练对心力衰竭患者的抑郁症状提供了适度的减轻.
- 这些抑郁症状改善的临床意义需要进一步研究.
- 有氧运动可能是心力衰竭管理的有益辅助疗法.
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