通过心血管磁共振量化的细胞外矩阵扩张与短期死亡率之间的关联
Timothy C Wong1, Kayla Piehler, Christopher G Meier
1Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Circulation
|August 2, 2012
概括
细胞外矩阵扩张,以细胞外体积分数 (ECV) 衡量,与心脏病患者的死亡风险增加有关. 这种新的心血管磁共振技术有助于对不良结果的风险分层.
科学领域:
- 心血管成像 - 心血管成像
- 心肌重塑是指心肌的重塑.
- 生物标志物发现发现
背景情况:
- 细胞外矩阵扩张是心肌逆向重塑的一个关键特征.
- 精确测量细胞外矩阵是具有挑战性的,但对于风险分层至关重要.
- 新的心血管磁共振技术可以量化常规方法无法检测到的细胞外矩阵扩张.
研究的目的:
- 评估细胞外矩阵扩张和患者死亡率之间的关系.
- 利用先进的心血管磁共振来量化细胞外基质.
- 评估细胞外矩阵扩张对心脏不良结果的预测价值.
主要方法:
- 招募了793名患者和9名健康志愿者进行心血管磁共振.
- 量化细胞外矩阵扩张使用细胞外体积分数 (ECV) 通过gadolinium对比和T1成像.
- 使用考克斯回归分析了ECV与全因死亡率和复合终点的关系.
主要成果:
- 患者的ECV值在21.0%至45.8%之间,表明显著的细胞外矩阵扩张.
- 增加的ECV与所有原因死亡率 (HR 1.55) 和复合终点 (HR 1.48) 显著相关,每增加3%.
- 结果根据年龄,左心室喷射率和心肌梗塞大小进行了调整.
结论:
- 细胞外体积分数 (ECV) 测量有效量化心肌细胞外矩阵扩张.
- 脑电流是死亡率和复合性心脏不良事件的有价值预测指标.
- 这种技术为患有心脏病的患者提供了改善的风险分层.
相关概念视频
01:42The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.Composition of the Extracellular MatrixThe extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse molecules.
01:29The Extracellular Matrix
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
01:26Extracellular Matrix
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...