升坡式双相波形具有较低的除门,并且释放的 I 素比截断的指数双相波形更少
Jian Huang1, Gregory P Walcott, Richard B Ruse
1University of Alabama-Birmingham, 1670 University Blvd, Room B140 Volker Hall, Birmingham, AL 35294-0019, USA. jh@crml.uab.edu
Circulation
|August 7, 2012
概括
电击波形状的形状显著影响除成功和心脏损伤. 上升的坡道波形显示出更低的除能量需求和更少的托波宁I释放,表明肌肉心脏损伤减少.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 电子生理学 电子生理学
背景情况:
- 电动除的有效性受冲击波形特征的影响.
- 了解波形形状如何影响除门和心脏损伤对于优化复苏方案至关重要.
研究的目的:
- 调查冲击波形状影响除门和心脏损伤的假设.
- 为了比较与各种电击波形相关的除功效和心肌损伤.
主要方法:
- 在猪中确定了11种不同波形 (上升,下降,直线双相,古尔维奇,截断的指数双相) 的除门.
- 给出一次约30-J的冲击来诱导除,并测量了冲击后的热素I血水平,以评估心脏损伤.
主要成果:
- 8毫秒的上升坡道波形表现出最低的除门 (14.6±7.3 J).
- 升坡波形导致冲击后6小时I型热素水平显著降低 (0.80±0.54 ng/mL),与截断的指数 (1.92±0.47 ng/mL) 和直线波形 (1.17±0.45 ng/mL) 相比.
结论:
- 相比于截断的指数双相冲击,上升坡道波形表现出较低的除门,并导致心脏损伤明显减少 (58%较少的托罗邦素I释放).
- 冲击波形特征在除的有效性和心肌损伤的程度上起着至关重要的作用.
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