通过氧球蛋白模型的氧化氧化氧化氧化氧化反应:在现场低温FTIR对协调过氧酸的表征
Tigran S Kurtikyan1, Shahane R Eksuzyan, Vardan A Hayrapetyan
1Molecule Structure Research Centre (MSRC) of the Scientific and Technological Centre of Organic and Pharmaceutical Chemistry NAS, 0014, Yerevan, Armenia. kurto@netsys.am
Journal of the American Chemical Society
|August 14, 2012
概括
球蛋白模型与氧化和二氧化反应,形成过氧和酸盐复合物. 这些发现表明,球蛋白模型能够模仿氧反应,形成酸盐产物.
科学领域:
- 生物有机化学 生物有机化学
- 协调化学 协调化学
- 频谱学是一种光谱学.
背景情况:
- 合成的科博格洛宾模型模仿了天然血红蛋白的功能.
- 了解这些模型与氧化和二氧化等小分子的反应性对于生物无机化学至关重要.
研究的目的:
- 为了研究 oxy-coboglobin 模型与氧化的反应途径.
- 描述反应过程中形成的中间和最终产品.
主要方法:
- 用氨酸连接剂合成氧球蛋白模型.
- 低温光谱 (FTIR和UV可见) 用于监测反应.
- 同位素标记实验中使用的同位素是 (18) O, (2) (15) NO 和 N, (18) O.
- 密度函数理论 (DFT) 的计算.
主要成果:
- 在从80°C到120°C升温后形成六坐标过氧酸盐复合物 ((NH(3)) Co(Por) ((OONO)) .
- 过氧酸盐复合物的分解和二氧化 (NO2) 的形成在140和170K之间.
- 在180-210 K时形成六坐标酸盐复合物 ((NH(3)) Co(Por) (((η(1) -ONO(2)),表明氧化二氧化氧化 (NOD).
结论:
- 氧基球蛋白模型促进氧化二氧化氧化 (NOD) 反应,类似于氧化.
- 六坐标酸盐复合物在室温下不稳定,分离成酸盐和氧化合物复合物.
- 这项研究提供了关于 - 氨酸复合物与小分子反应机制的见解.
相关概念视频
Nitrosation of Enols
6.2K
The nitrosation reaction is one of the methods of preparing 1,2-diketones. The enol tautomer of the starting ketone reacts with sodium nitrite in hydrochloric acid, generating the 1,2-diketone after hydrolysis.
6.2K
Preparation of Amines: Reduction of Oximes and Nitro Compounds
4.2K
Oximes can be reduced to primary amines using catalytic hydrogenation, hydride reduction, or sodium metal reduction. The reduction of aliphatic and aromatic nitro compounds to primary amines takes place by either catalytic hydrogenation or by using active metals like Fe, Zn, and Sn in the presence of an acid.
Though catalytic hydrogenation can reduce nitrobenzenes, the reduction is nonselective in the presence of other functional groups. For instance, if nitrobenzene contains an aldehyde group,...
Though catalytic hydrogenation can reduce nitrobenzenes, the reduction is nonselective in the presence of other functional groups. For instance, if nitrobenzene contains an aldehyde group,...
4.2K
Oxygen Transport in the Blood
4.6K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
4.6K
Lewis Structures of Molecular Compounds and Polyatomic Ions
41.4K
To draw Lewis structures for complicated molecules and molecular ions, it is helpful to follow a step-by-step procedure as outlined:
41.4K
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
11.4K
Alkenes are converted to 1,2-diols or glycols through a process called dihydroxylation. It involves the addition of two hydroxyl groups across the double bond with two different stereochemical approaches, namely anti and syn. Dihydroxylation using osmium tetroxide progresses with syn stereochemistry.
11.4K
Oxidation of Phenols to Quinones
3.8K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
3.8K


