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多EGCG在脂接口上抑制粉样蛋白形成的效率不如散装溶液中的效率

Maarten F M Engel1, Corianne C vandenAkker, Michael Schleeger

  • 1FOM Institute AMOLF, Science Park 104, 1098 XG, Amsterdam, The Netherlands.

Journal of the American Chemical Society
|August 15, 2012
PubMed
概括

(-) -epigallocatechin gallate (EGCG) 在抑制细胞膜中的粉样蛋白形成方面效果不如溶液中的效果. 这种常见的粉样蛋白抑制剂也未能在接口处分解现有的纤维,这凸显了在药物设计中需要考虑膜效应的必要性.

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