针对同时出现的创伤后应激障碍和物质依赖的基于暴露的综合治疗:随机对照试验
Katherine L Mills1, Maree Teesson, Sudie E Back
1National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia 2052. k.mills@unsw.edu.au
JAMA
|August 16, 2012
概括
使用长期暴露 (COPE) 对PTSD和物质使用障碍的同时治疗显著减少了患有PTSD和物质依赖同时发生的患者的PTSD症状. 这种综合方法改善了PTSD症状严重程度,而没有恶化物质依赖.
科学领域:
- 精神病学和行为科学 精神病学和行为科学
- 成 药物 药物 药物 药物
- 创伤研究 创伤研究
背景情况:
- 对创伤后应激障碍 (PTSD) 的暴露疗法引起了人们对同时出现物质依赖症的患者复发的担忧.
- 综合治疗方法可能是必要的,以有效地解决这两种情况.
研究的目的:
- 评估使用长期暴露 (COPE) 的PTSD和物质使用障碍同时治疗的疗效,与对物质依赖的通常护理相比.
- 为了确定COPE是否可以减少PTSD和物质依赖症的症状严重程度.
主要方法:
- 一项随机对照试验,涉及103名被诊断患有PTSD和物质依赖的参与者.
- 参与者被随机分配,接受COPE加常规治疗或仅接受常规治疗.
- 结果,包括PTSD和物质依赖症状严重程度,在基线后9个月被评估.
主要成果:
- 与通常治疗组相比,COPE组显示PTSD症状严重程度的显著降低 (平均差异为-16.09).
- 两组都经历了PTSD症状的减少,但综合治疗产生了更好的结果.
- 在改善物质依赖严重程度,物质使用,抑郁或焦虑方面,没有观察到群体之间的显著差异.
结论:
- 将COPE与常规治疗相结合,可以改善伴随性PTSD和物质依赖症患者的PTSD症状严重程度.
- 这种综合方法在不加剧物质依赖症状的情况下是有效的.
- 对于那些面临PTSD和物质使用障碍双重挑战的人来说,COPE是一个可行的治疗选择.
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