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Updated: May 19, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

PKM2可酸化基因组H3并促进基因转录和瘤发生

Weiwei Yang1, Yan Xia, David Hawke

  • 1Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Cell
|August 21, 2012
PubMed
概括

瘤蛋白PKM2直接修改了基因组H3,影响了基因转录和脑瘤生长. 这种蛋白激酶活性对表观遗传调节至关重要,并提供潜在的治疗点.

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