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通过Parp1和Tet2进行体细胞重编程的早期表观遗传修饰

Claudia A Doege1, Keiichi Inoue, Toru Yamashita

  • 1Department of Pathology, Taub Institute for Aging, Columbia University, New York, New York 10032, USA.

Nature
|August 21, 2012
PubMed
概括

在诱导多能干干细胞 (iPSC) 重编程过程中的早期表观遗传变化中,Poly (ADP-ribose) 聚合酶-1 (Parp1) 和十-十一转位-2 (Tet2) 是至关重要的. 这些因素建立了独特的表观遗传标记,促进了多能性基因的激活.

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