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相关概念视频

Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
The DNA Helix01:16

The DNA Helix

Overview

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相关实验视频

Updated: May 19, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

下一代数字信息存储在DNA中的数据.

George M Church1, Yuan Gao, Sriram Kosuri

  • 1Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|August 21, 2012
PubMed
概括

科学家们将5.27兆比特的书籍编码到DNA中,证明了其作为密集和稳定的数字存储媒介的潜力. 这一突破利用了DNA合成和测序技术的进步,用于未来的数据存档.

科学领域:

  • 生物技术是生物技术.
  • 生物信息学是一种生物信息学.
  • 数据存储数据存储数据存储

背景情况:

  • 数字数据的指数式增长需要新的,高密度和长期的存档解决方案.
  • 目前的储存方法在密度,稳定性和寿命方面存在局限性.
  • 脱氧核糖核酸 (DNA) 提供了无与伦比的信息密度和特殊的稳定性.

研究的目的:

  • 开发和验证一种将任意数字数据编码到DNA中的方法.
  • 通过使用DNA来证明写入和阅读大量数字信息的可行性.
  • 评估DNA作为数字信息存储和归档的实用媒介的可行性.

主要方法:

  • 设计了一种新的策略,将数字二进制数据转换为DNA序列.
  • 使用DNA合成技术,将编码信息物理写入DNA微芯片上.
  • 使用下一代DNA测序来检索和解码存储的数字信息.

主要成果:

  • 在DNA分子中成功编码和合成了一本5.27兆比特的数字书.
  • 从合成的DNA中实现了完整数字图书的准确检索和重建.
  • 证明了DNA对数字信息的高密度存储能力.

更多相关视频

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

相关实验视频

Last Updated: May 19, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
07:50

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

结论:

  • DNA合成和测序技术为数字数据存储提供了可行的途径.
  • DNA微芯片为存储大量数字信息提供了一个强大的平台.
  • 这项研究证实了DNA是长期,高密度数据存档的有希望的媒介.