分支多功能聚乙烯多基:基组结构的变化使得在溶液和细胞内对聚合物降解的前所未有的控制
Rajesh A Shenoi1, Jayaprakash K Narayanannair, Jasmine L Hamilton
1Centre for Blood Research and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.
Journal of the American Chemical Society
|August 22, 2012
概括
研究人员开发了新的生物降解聚合物,称为聚基乙烯 (PKHEs),具有可调节的降解率,用于先进的纳米医学. 这些多功能纳米材料显示出出色的生物相容性和细胞内的受控分解.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 纳米医学是一种纳米医学.
背景情况:
- 开发多功能,生物相容和可生物降解的纳米材料对于有针对性的纳米医学至关重要.
- 现有的材料往往缺乏精确控制降解概况和刺激反应.
研究的目的:
- 合成和表征一种新型的多功能树突型聚乙烯聚乙烯基乙烯 (PKHEs) 的新型类.
- 为了实现前所未有的控制聚合物降解率在溶液和细胞内.
- 评估PKHE在纳米医学应用中的生物相容性和潜力.
主要方法:
- 新型AB(2) 型单体的环开放多分支聚合.
- 聚合物功能化与亚酸和氨基群.
- 在轻度酸性pH下进行水解研究,以确定降解动力学.
- 使用共聚焦显微镜进行细胞降解研究.
- 生物相容性评估 (MTS测定,血液相容性测试).
主要成果:
- 成功合成了具有可调节性质的高分子量,紧的PKHE.
- 根据基组结构和疏水性,对聚合物降解速率 (分钟至数百天) 进行了精确的控制.
- 在活细胞内证实了类似的降解概况,导致细胞质递送标记物.
- PKHEs及其降解产品具有很高的生物相容性和血液相容性.
结论:
- 这种新一类可生物降解的PKHEs提供可调节的降解,使纳米医学能够精确控制.
- 已证明的生物相容性和细胞内降解使PKHEs在向药物输送和其他纳米医学应用中非常有前途.
相关概念视频
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