非线性树突处理决定了 in vivo 桶皮层神经元的角调整
Maria Lavzin1, Sophia Rapoport, Alon Polsky
1Department of Physiology, Rappaport Faculty of Medicine & Research Institute, Technion-Israel Institute of Technology, Bat-Galim, Haifa 31096, Israel.
Nature
|September 4, 2012
概括
第4层神经元使用活跃的树突融合,特别是N-甲基-D-酸盐 (NMDA) 尖峰,来放大感官反应. 这种机制通过在皮层中优先放大首选的刺激来提高神经元调的敏度.
科学领域:
- 神经科学是一个神经科学.
- 感官处理 感官处理
- 皮层电路中的皮层电路.
背景情况:
- 感官皮层中的4层神经元具有特征选择性.
- 现有的模型专注于体质整合,忽视了树突性角色.
- 活跃树突整合在感官响应放大和调中的作用还没有得到充分研究.
研究的目的:
- 研究4层神经元中活跃树突融合的作用.
- 确定树突机制是否会放大感官反应,并提高调曲线.
- 阐明N-甲基-D-酸盐受体 (NMDAR) 尖端对神经元功能的贡献.
主要方法:
- 在体内全细胞记录在皮层的皮质层4 棘状星状神经元.
- 使用的细胞内N-甲基-D-酸盐受体 (NMDAR) 阻断剂.
- 采用了膜超极化技术.
主要成果:
- 第4层神经元的树突会产生局部和全球的多分支N-甲基-D-酸盐 (NMDA) 尖峰.
- NMDA受体 (NMDAR) 的再生机制超线性地总结了协同激活的输入.
- 树突NMDAR-依赖的反应通过放大偏好的方向显著增强角度调.
结论:
- 活性树突N-甲基-D-酸盐 (NMDA) 尖峰是4层神经元中关键的再生事件.
- 树突性NMDAR放大机制对感官反应有显著的贡献.
- 这些树突机制决定了皮层神经元的调特性.
相关概念视频
The Role of Ion Channels in Neuronal Computation
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.
The Cochlea
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.


