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大动脉硬,血压进展,以及发生的高血压
Bernhard M Kaess1, Jian Rong, Martin G Larson
1National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA.
JAMA
|September 6, 2012
概括
增加的大动脉刚性和前进波幅预测更高的血压和高血压风险. 然而,初始血压并不能预测未来的大动脉硬化,强调硬度是高血压发展的关键因素.
科学领域:
- 心血管研究的心血管研究.
- 衰老和健康 衰老和健康
- 高血压研究研究高血压研究.
背景情况:
- 血管硬性随着年龄的增长而增加,对发病率和死亡率构成重大风险.
- 血管硬化和高血压之间的时间联系需要进一步澄清.
研究的目的:
- 为了研究血管硬,中央血液动力学,微血管功能和血压进展之间的时间关系.
- 分析血管硬度的测量如何预测未来的血压和高血压.
主要方法:
- 一项基于社区的纵向队列研究,使用来自弗雷明汉子女研究 (N=1759) 的数据.
- 在7年的时间内检查了血压与三个血管硬度度 (心骨脉冲波速率[CFPWV],前向波幅[FWA],增强指数) 之间的时间关联.
- 主要结局包括血压和事件高血压;次要结局是血管硬度的测量.
主要成果:
- 周期7中的更高的FWA和CFPWV与周期8中的更高的缩血压有关.
- 在第7周期增加的FWA,增强指数和CFPWV在第8周期预测事件高血压.
- 第7周期的初始血压并没有预测第8周期的CFPWV,但手臂动脉流动和流动介导扩张与发生的高血压有关.
结论:
- 增加的大动脉硬度,FWA和增大指数与患高血压的风险增加有关.
- 最初的血压水平不能独立地预测随着时间的推移大动脉硬化的进展.
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