单体顺序对可生物降解的多重聚合物 (乳酸-co-糖酸) 重复序列共聚合物的水解的影响
Jian Li1, Sam N Rothstein, Steven R Little
1Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Journal of the American Chemical Society
|September 7, 2012
概括
与随机的PLGA相比,对测序的Poly (乳酸-co-糖酸) (PLGA) 共聚合物进行研究,发现降解速度更慢,更稳定,药物释放受控. 这种序列控制为材料设计提供了新的可能性.
科学领域:
- 聚合物科学 聚合物科学
- 材料科学 材料科学 材料科学
- 生物材料是一种生物材料.
背景情况:
- 聚乳-同-甘油酸 (PLGA) 是一种重要的可生物降解共聚合物,广泛用于药物输送和组织工程.
- 目前,PLGA主要以随机的,无序的形式使用,这限制了其潜在的材料特性.
- 聚合物中的单体序列可以显著影响材料的多样性和性能,这是PLGA很少探索的一个因素.
研究的目的:
- 为了研究单体序列对Poly (乳酸-co-糖醇酸) (PLGA) 共聚合物的特性的影响.
- 为了比较测序的PLGA微粒与随机的PLGA微粒的降解速率和体外释放概况.
- 探索PLGA中的序列控制如何影响药物输送等应用中的材料性能.
主要方法:
- 合成和制造测序和随机的Poly (乳酸-co-葡萄糖酸) (PLGA) 微粒.
- 通过分子量减少,乳酸释放和热性质评估,分析降解速率.
- 在体外释放研究中,使用罗达胺-B作为装入PLGA微粒的模型剂.
主要成果:
- 与随机的PLGA共聚合物相比,测序的PLGA微粒显示出较慢和更稳定的降解速率,其乳酸和甘氨酸的比例相同.
- 同聚合物序列显著影响了模型剂 (罗达胺-B) 的体外释放.
- 测序的PLGA微粒显示出比它们的随机对应物更逐渐的爆发释放特征.
结论:
- 单体序列是一个关键因素,影响了多样乳糖合糖酸 (PLGA) 的降解行为和药物释放动力学.
- 测序PLGA为开发具有可控释放配置文件的先进药物递送系统提供了潜力.
- 这项研究强调了可生物降解共聚合物的序列控制对于量身定制的材料设计的重要性.
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