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细胞通信的选择性沉默影响了C. elegans中前后形状的形成

D A Waring¹, C Kenyon

¹Department of Biochemistry and Biophysics, University of California, San Francisco 94143.

|January 12, 1990

概括

细胞与细胞的相互作用和pal-1基因调节了Caenorhabditis elegans V细胞的命运. 这种发育转换器决定了细胞是否形成alea或rays,这对男性发育至关重要.

科学领域:

发育生物学是发展生物学.
遗传学是一个遗传学.
细胞生物学细胞生物学

背景情况:

在Caenorhabditis elegans雄性中,V细胞形成前侧 (结状脊) 和后侧 (交配感觉).
控制前V细胞和后V细胞不同的命运的精确机制尚未完全理解.

研究的目的:

为了研究V细胞命运如何在C. elegans雄性中确定.
阐明细胞与细胞相互作用和pal-1基因在这个过程中的作用.

主要方法:

对C. elegans基因活动的分析.
研究细胞在发育过程中的细胞相互作用.
研究Pal-1,Lin-22和Mab-5基因的功能.

主要成果:

细胞与细胞的相互作用会诱导前V细胞形成状细胞.
帕尔-1基因抑制后部V细胞中的这些相互作用,导致射线形成.
一个涉及lin-22和mab-5的发育开关受到细胞信号和pal-1的影响.

结论:

在C. elegans雄性中,V细胞命运的确定涉及选择性中断细胞与细胞相互作用.
帕尔-1基因通过抑制alae诱导相互作用,在指定后部V细胞命运方面发挥着关键作用.
发育命运是由细胞信号和特定基因调节的开关控制的.

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