慢性心力衰竭中的厌氧值. 与血液乳酸的关系,呼吸基础,可重复性,以及对运动训练的反应
1Department of Medicine, Durham, NC 27710.
Circulation
|January 1, 1990
概括
气体交换 (ATge) 的无氧值是慢性心力衰竭 (CHF) 患者功能能力的可靠指标. 运动训练改善了ATge,提高了运动耐受性和高峰氧气消耗 (VO2).
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 肺部医学 肺部医学
背景情况:
- 慢性心力衰竭 (CHF) 患者的运动耐受性降低,影响功能障碍.
- 气体交换 (ATge) 的无氧值是评估CHF的功能能力和治疗反应的潜在生物标志物.
- 了解运动期间的呼吸道,血液动力学和代谢反应对于治疗心血管疾病至关重要.
研究的目的:
- 通过气体交换 (ATge) 评估厌氧值,以衡量慢性心力衰竭 (CHF) 中的功能障碍.
- 评估ATge测量的可重现性和可靠性在CHF患者和健康个体.
- 为了确定运动训练对ATge的影响和CHF患者的运动耐受性.
主要方法:
- 在64名心血管衰竭患者和38名对照人群中进行了最大限度的自行车运动测试,测量了呼吸系统,血液动力学和代谢反应.
- 在18名CHF患者和18名对照组中,使用通风器等效法 (VE/VO2和VE/VCO2) 确定了ATge.
- 评估了ATge的可重现性和观察者间的变异性;12名CHF患者接受了4-6个月的运动训练计划.
主要成果:
- 慢性肺炎患者出现了增加的通风与二氧化碳生产比率 (VE/VCO2),与增加的死空间与潮体积比率 (Vd/Vt) 相关.
- 在大多数患者和对照组中,ATge是可识别的,表现出良好的可重复性和低的观察者间变异性.
- 运动训练使VO2峰值提高了23%,ATge VO2从10.1升至12.1毫升/千克/分钟,并使CHF患者的运动持续时间延长.
结论:
- 气体交换 (ATge) 的无氧值是一个可重复和可靠的参数,用于评估慢性心力衰竭 (CHF) 的功能能力.
- 运动训练有效地改善了ATge,并增强了CHF患者的运动耐受性.
- ATge是监测旨在改善CHF运动能力的治疗干预措施的宝贵工具.
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