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增加了HIV-1疫苗对Env V2中具有遗传特征的病毒的疗效

Morgane Rolland1, Paul T Edlefsen, Brendan B Larsen

  • 1US Military HIV Research Program, Silver Spring, Maryland 20910, USA. mrolland@hivresearch.org

Nature
|September 11, 2012
PubMed
概括

在RV144疫苗试验中,对HIV-1感染的部分保护. 针对HIV包膜V2区域特定部位的免疫反应与感染风险降低有关,这表明对突破性病毒有选效应.

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Viral Mutations00:36

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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...