在缺血性心脏病中补充系统
M Yasuda1, K Takeuchi, M Hiruma
1First Department of Internal Medicine, Osaka City University Medical School, Japan.
Circulation
|January 1, 1990
概括
补充系统的激活发生在急性心肌梗塞 (AMI) 中,并与心脏损伤有关. 轻度激活在不稳定的心痛中可见,但不是稳定的心痛,没有心脏功能障碍.
科学领域:
- 心血管医学 心血管医学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 急性心肌梗塞 (AMI) 后的组织损伤机制尚不清楚.
- 实验模型表明,在AMI相关的微血管和宏血管损伤中,补充系统的参与.
- 胸痛中补充激活的作用还没有很好地定义.
研究的目的:
- 研究补充系统作为心肌炎症调解者的作用.
- 在AMI患者,不稳定性胸痛,稳定性胸痛和健康志愿者中量化补充激活产品.
- 评估补充激活和心肌损伤之间的关联.
主要方法:
- 在血样本中的补充激活产品 (C3d,C4d,Bb,SC5b-9) 的量化.
- 研究包括31名AMI患者,17名不稳定性胸痛患者,19名稳定性胸痛患者和20名正常志愿者.
- 分析了SC5b-9水平和峰值肌酸基酶,射出分数和心力衰竭状态之间的相关性.
主要成果:
- 血C3d水平在AMI和不稳定性胸痛患者中升高 (p<0.01).
- 血C4d,Bb和SC5b-9的水平仅在AMI患者中增加 (p<0.01).
- 血SC5b-9水平与肌酸基酶 (r=0.71) 相对相关,反向与射出分数 (r=-0.71),并且在心力衰竭的AMI患者中较高.
结论:
- 补充系统的激活在AMI后是显而易见的,并与心肌损伤相关.
- 轻度补充系统激活发生在不稳定的胸痛中,而没有心脏功能障碍.
- 补体系统在稳定性胸痛中没有被激活.
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