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通过选择性胆固醇抑制预防富血小板的动脉血栓形成
I K Jang1, H K Gold, A A Ziskind
1Cardiac Unit, Massachusetts General Hospital, Boston 02114.
Circulation
|January 1, 1990
概括
肝素对子的动脉血栓形成无效,但合成血栓抑制剂阿格拉特罗班显著阻止了血栓形成. 这表明选择性血栓抑制是预防动脉封闭的一个有希望的方法.
科学领域:
- 心血管研究研究心血管研究
- 药理学 药理学是指药理学的学科.
- 血栓形成研究研究
背景情况:
- 富有血小板的动脉血栓是心血管事件的关键因素.
- 氨酸是一种常见的抗凝剂,在预防动脉血栓形成方面具有局限性.
- 血在动脉血栓形成的病变中起着关键作用.
研究的目的:
- 在子模型中比较氨酸和阿格拉斯托班在预防富有血小板的动脉血栓的疗效.
- 为了研究血栓在动脉血栓形成中的作用.
- 评估阿格拉斯罗班作为预防动脉堵塞的潜在治疗剂.
主要方法:
- 一个子大腿动脉模型与一个 everted 段被用来诱导血栓形成.
- 动物接受了静脉内或动脉内注射的氨酸或阿格拉斯罗班.
- 输血后60分钟和3小时内监测了血栓的发展和动脉通透度.
- 测量了血栓激素时间和部分血栓塑时间.
主要成果:
- 静脉注射肝素未能在所有子中预防动脉堵塞.
- 静脉输入的阿斯拉夫罗班在13只子中的9只中预防了血栓形成 (p = 0.002与肝素相比).
- 静脉内给药的阿斯罗班比静脉内给药的肝素有效得多,在所有子中预防了血栓形成 (p = 0.00001 与肝素对比).
- 阿尔加特罗班保持了动脉通透性,并显示了最小的血小板聚合或纤维素沉积.
结论:
- 血栓激素在富含血小板的动脉血栓症中至关重要.
- 短期的阿斯拉特罗班输液有效地减轻了血栓刺激.
- 选择性血栓抑制为预防血管形成或血栓溶解后动脉封闭提供了一个潜在的替代方案.
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