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左心室血液动力负荷和收缩性能与高血压中左心室质量的关系
A Ganau1, R B Devereux, T G Pickering
1Cardiovascular and Hypertension Center, New York Hospital-Cornell Medical Center, NY 10021.
Circulation
|January 1, 1990
概括
高血压的左心室质量受房间大小和收缩性的影响,而不仅仅是血压. 这项研究表明,高缩与血液动力负荷保持一致,而腔体体积是关键因素.
科学领域:
- 心脏病学 心脏病学
- 身体生理学 身体生理学
- 生物医学工程 生物医学工程
背景情况:
- 缩血压与左心室质量之间的弱相关性表明,非血液动力学因素影响高血压中的心肌生长.
- 了解左心室腔大小,血液动力负荷和心肌收缩率的作用对于解释心肌缩发展至关重要.
研究的目的:
- 测试假设左心室腔大小,反映血液动力学体积负荷和收缩性,影响左心室缩在高血压.
- 为了研究左心室质量与室体积,压力,负载和高血压患者的收缩性之间的关系.
主要方法:
- 在50名正常患者和50名未经治疗的基本高血压患者中利用M模式和二维回声心电图.
- 评估左心室负荷使用总负荷和峰值午线力指数.
- 基于缩血压和终端-透缩直径计算理论上最佳的左心室质量.
主要成果:
- 左心室质量与静心血压 (r=0.45) 相比,与终端透缩体积 (r=0.56) 和总负荷/峰值午线力 (r=0.68-0.70) 相比,与静心血压 (r=0.45) 更好地相关.
- 多变量分析显示,末端透气体积和血压是左心室质量的独立预测指标 (R=0.75).
- 实际和理论上最佳的左心室质量是密切相关的 (r=0.76),表明缩并行血液动力负荷.
结论:
- 高血压中的左心室缩受室大小和血液动力负荷的显著影响,而不仅仅是血压.
- 腔体积,中风指数和收缩率是左心室质量的关键决定因素,共同解释了其可变性的很大一部分.
- 这些发现挑战了对血压-质量关系弱的解释,仅仅是非血动力学,突出了腔室尺寸的重要性.
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