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RNF168在H2A/H2AX上无处不在的K13-15驱动DNA损伤信号传递

Francesca Mattiroli1, Joseph H A Vissers, Willem J van Dijk

  • 1Division of Biochemistry and Center for Biomedical Genetics, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

Cell
|September 18, 2012
PubMed
概括

在DNA损伤反应过程中,RNF168,而不是RNF8,在K13-15处单双化基因组H2A/H2AX. 这种特定的基因素无所不在化,而不仅仅是无所不在链,对于信号传输至关重要.

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