工作压力是冠心病的风险因素:对个人参与者数据的协作元分析
Mika Kivimäki1, Solja T Nyberg, G David Batty
1Department of Epidemiology and Public Health, University College London, London, UK. m.kivimaki@ucl.ac.uk
Lancet (London, England)
|September 18, 2012
概括
工作压力或工作场所压力与冠心病的风险更高有关. 虽然防止工作压力可能有所帮助,但它比解决吸烟等主要风险因素的影响要小.
科学领域:
- 职业健康 职业健康 职业健康 职业健康
- 心血管流行病学心血管流行病学
- 心理社会风险因素 心理社会风险因素
背景情况:
- 现有的关于工作压力和冠心病 (CHD) 的研究不一致,人们担心出版和反向因果偏见.
- 这一元分析的目的是通过使用全面的数据集来澄清工作压力和心血管疾病之间的关联.
研究的目的:
- 调查工作压力与冠心病发病率之间的关系.
- 通过对已公布和未公布数据的元分析,解决先前研究中的潜在偏差.
主要方法:
- 分析了来自13项欧洲队列研究 (1985-2006) 的个人参与者数据.
- 用验证的问卷来评估工作压力;冠心病包括非致命的心肌梗塞或冠心病死亡.
- 分析通过排除早期发病事件来考虑潜在的反向因果关系.
主要成果:
- 工作压力与23%的冠心病风险增加有关 (HR 1.23).
- 在对各种混因素进行调整后,在排除早期事件的分析中,这种关联仍然显著.
- 人口可归因的工作压力风险估计为3.4%.
结论:
- 工作压力是冠状动脉心脏病的重要危险因素.
- 工作场所压力预防可以降低心脏病发病率,但效果不如管理已确定的风险因素,如吸烟.
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