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为光激活抗癌复合体的酸开关
Jennifer S Butler1, Julie A Woods, Nicola J Farrer
1Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
Journal of the American Chemical Society
|September 21, 2012
概括
(IV) 复合物trans,trans,trans-[Pt (N3) 2 (OH) 2 (py) 2) (1) 在蓝光照射时显示出强烈的癌细胞毒性. 这种效应被l-二关闭,它灭了亚基的形成.
科学领域:
- 无机化学 无机化学 有机化学
- 摄影化学的使用.
- 癌症治疗方法 癌症治疗方法
背景情况:
- (IV) 复合物正在研究用于癌症治疗.
- 光活性复合物可以表现出强烈的细胞毒性.
研究的目的:
- 为了研究特定的Pt(IV) 复合物的光细胞毒性机制.
- 探索l-三在调节这种光细胞毒性的作用.
主要方法:
- 电子偏磁共振 (EPR) 光谱学
- 核磁共振 (NMR) 光谱学 核磁共振 (NMR) 光谱学
- 螺旋捕获技术 螺旋捕获技术
主要成果:
- 在可见光下,Pt(IV) 复合体trans,trans,trans-[Pt(N3) 2(OH) 2(py) 2) (1) 对癌细胞具有细胞毒性.
- 低剂量 (500微米) 的l-三 (l-Trp) 抑制了这种光细胞毒性.
- EPR和NMR研究表明,l-Trp通过作为电子捐赠体来灭亚基的形成.
结论:
- 酸可以控制光化疗酸Pt (IV) 药物的活性.
- 涉及激素和Pt(II) 光产物的双重攻击机制有助于这些复合物的强度.
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