由BATF-IRF相互作用中介的补偿性树突细胞的发展
Roxane Tussiwand1, Wan-Ling Lee, Theresa L Murphy
1Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA.
Nature
|September 21, 2012
概括
研究人员在感染期间发现了一条BATf3独立的途径,用于开发CD8α(+) 树突细胞. 这种涉及Batf和Batf2的替代途径补偿了Batf3,并可以增强疫苗反应.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- AP1转录因子Batf3对于CD8α(+) 树突细胞发育和T细胞对抗细胞内病原体的原始化至关重要.
- 了解树突细胞发育是调节免疫反应的关键.
研究的目的:
- 为了确定CD8α(+) 树突细胞发展的替代途径,独立于Batf3.
- 探索补偿转录因子在免疫反应中的作用.
主要方法:
- 研究了小鼠在细胞内病原体感染期间的树突细胞发育.
- 分析了Batf,Batf2,IL-12和干扰素-γ在补偿Batf3.3中的作用.
- 研究了涉及氨酸拉链域和IRF4/IRF8.8的分子相互作用.
主要成果:
- 在感染期间通过IL-12和干扰素-γ调解的CD8α(+) 树突细胞发育的Batf3独立途径.
- 通过相关的AP1因子Batf和Batf2对Batf3.3进行证明的分子补偿.
- 在T细胞中显示了Batf和Batf3之间对IL-10和CTLA4表达的相互补偿.
- 揭示了BATF因子通过与IRF4和IRF8.8相互作用的共享leucine拉链域进行补偿.
结论:
- 树突细胞发育的另一个途径存在,由Batf,Batf2,IL-12和干扰素γ介导,补偿Batf3.3.
- 这种补偿机制突显了免疫细胞发育的可塑性.
- 针对这种替代途径可能提供增强免疫反应的策略,可能用于疫苗开发.
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