确定和维持家养和野猫的色素模式
Christopher B Kaelin1, Xiao Xu, Lewis Z Hong
1HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA.
概括
科学家们发现,跨膜氨基酶Q (Taqpep) 基因是猫科动物毛皮图案的关键,包括国王猎. 该基因与Endothelin3 (Edn3) 一起,通过两阶段的发育过程解释了各种猫的标记.
科学领域:
- 遗传学 遗传学 是一个
- 发展生物学 发展生物学
- 动物学 动物学
背景情况:
- 猫的毛皮图案表现出各种各样的,但周期性的变化.
- 家庭猫的标签图案表明一种受选择影响的保存遗传机制.
研究的目的:
- 为了确定家养猫的标签模式变化的遗传基础.
- 调查已识别的基因在31种类动物的外套模式多样性中的作用.
- 为了阐明猫毛发型的发展背后的分子机制.
主要方法:
- 在家猫中基因鉴定和测序.
- 在31种类动物中进行比较基因组分析.
- 基因组学,基因表达和转基因小鼠研究.
- 对Endothelin3 (Edn3) 表达模式的分析.
主要成果:
- 发现了跨膜氨基酶Q (Taqpep) 基因,该基因负责家猫的标签模式.
- 塔克佩普也被确定为国王猎独特的斑点和条纹表型的原因.
- 发现Endothelin3 (Edn3) 的近表达能协调局部色彩差异.
结论:
- 提出了一种用于猫毛发型的两阶段模型.
- 在皮肤发育过程中,Taqpep建立了一个周期性的前模式.
- 不同的Edn3表达随后实现了该模式,解释了不同的猫色.
相关概念视频
Epistasis
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
Background and Environment Affect Phenotype
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Pigmentation
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Mate Choice
Mate choice—the decision about whom to mate with—is a type of natural selection, since animals must reproduce to pass down their genes. Mate choice is also called intersexual selection because the behavior occurs between the sexes.
X-Inactivation
The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
Types of Selection
Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...


