怀孕印制了调节性记忆,维持了对胎儿抗原的反应
Jared H Rowe1, James M Ertelt, Lijun Xin
1University of Minnesota School of Medicine, Department of Pediatrics, Minneapolis, Minnesota 55455, USA.
Nature
|October 2, 2012
概括
孕期孕产妇FOXP3(+) 调节性T细胞 (Treg细胞) 的扩张对于胎儿的耐受性至关重要. 胎儿特异性Treg细胞在出生后持续存在,增强对未来怀孕的耐受性和免疫记忆力.
科学领域:
- 免疫学 免疫学 免疫学
- 生殖生物学 生殖生物学
背景情况:
- 母亲对胎儿的免疫耐受性对于成功怀孕至关重要.
- 母体FOXP3(+) 调节性T细胞 (Treg细胞) 的扩张对于维持这种耐受性至关重要.
- 干扰Treg细胞扩张与妊娠并发症有关.
研究的目的:
- 在怀孕期间定义孕产妇Treg细胞的抗原特异性和细胞起源.
- 为了研究胎儿特异性Treg细胞在分娩后和随后的怀孕期间的持久性和功能.
主要方法:
- 使用基于四聚胺的丰富剂来识别和分离罕见的内源性母体T细胞.
- 在怀孕期间和之后分析了FOXP3(+) CD4细胞群.
- 评估Treg细胞的增殖和功能在初级与二级怀孕.
主要成果:
- 怀孕可以选择性地扩大孕产妇的FOXP3 (((+) CD4细胞,使其具有胎儿特异性.
- 胎儿特异性Treg细胞在分娩后持续存在,保持耐受性,并在随后的怀孕中迅速重新积累.
- 二次妊娠Treg扩张依赖于保留的胎儿特异细胞,而初级怀孕涉及de novo诱导和增殖.
结论:
- 怀孕印记了母亲的FOXP3 (((+) CD4细胞,建立了对胎儿抗原的调控记忆.
- 这种调节性记忆增强了胎儿在随后的怀孕中对免疫挑战的耐受性和弹性.
- 结果表明,改善妊娠结果的新策略和Treg细胞记忆的治疗应用.
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