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通过A类β-乳酸酶进行卡巴烯水解的基础:使用晶体学和模拟的联合研究

Fátima Fonseca1, Ewa I Chudyk, Marc W van der Kamp

  • 1School of Cellular and Molecular Medicine, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, United Kingdom. maria.fonseca@ibmc.up.pt

Journal of the American Chemical Society
|October 4, 2012
PubMed
概括

碳烯水解类Aβ-乳酸酶是一个越来越大的威胁. 对Serratia fonticola carbapenemase SFC-1的结构分析揭示了这些酶如何有效地降解carbapenem抗生素.

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