帕拉催化的二聚体和选择性形式 [3 + 2] - 循环添加替代乙烯基cyclopropanes的循环添加

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Updated: May 18, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Barry M Trost1, Patrick J Morris, Simon J Sprague

  • 1Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. bmtrost@stanford.edu

Journal of the American Chemical Society
|October 4, 2012
PubMed
概括

这项研究引入了催化循环添加反应,从乙烯基cyclopropanes和olefins中形成高度替代的cyclopentanes. 该方法通过一种涉及远程立体感应的新机制实现了高立体选择性.

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