紧的化学分析仪可以有多可靠地测量脂质?
H W Kaufman1, J R McNamara, K M Anderson
1Framingham, Union Hospital, Boston, Mass.
JAMA
|March 2, 1990
概括
紧化学分析仪在脂质测量中显示了可变可靠性. 两个分析仪符合胆固醇的准确性标准,但整体性能不同,影响了根据国家胆固醇教育计划指南的患者分类.
科学领域:
- 临床化学 临床化学
- 实验室医学 实验室医学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 准确的脂质测量对于心血管疾病风险评估至关重要.
- 紧型化学分析仪为临床或分散的脂质检测提供了潜力.
- 这些设备的标准化评估是必要的,以确保可靠的临床结果.
研究的目的:
- 为了评估五个紧的化学分析仪的准确性和精度,以确定脂质.
- 评估分析仪结果与患者分类参考实验室的一致性.
- 为了确定这些分析仪是否符合国家胆固醇教育计划 (NCEP) 的指导方针.
主要方法:
- 用新鲜的血或血清样本测试了五个紧的化学分析仪.
- 在所有五个分析仪上测量了总胆固醇.
- 甘油三和高密度脂蛋白胆固醇是在能够进行这两种分析的分析仪上测量的.
- 评估了准确性,精度和与参考实验室的NCEP分类协议.
主要成果:
- 两个分析仪符合总胆固醇测量的准确性标准.
- 三个分析仪符合总胆固醇测量的精度标准.
- 对总胆固醇的NCEP分类的同意率在73%至96%之间,对低密度脂蛋白胆固醇的同意率较低.
结论:
- 紧化学分析仪显示脂质测量可靠性的变化.
- 性能差异影响了对心血管风险患者的准确分类.
- 小型分析仪的精心选择和验证对于临床使用至关重要.
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