在中部前额叶皮层的网络重置标志着行为不确定性的出现
Mattias P Karlsson1, Dougal G R Tervo, Alla Y Karpova
1Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA.
Science (New York, N.Y.)
|October 9, 2012
概括
在老鼠中,中部前额叶皮质活动的暂时增加信号波动的信念修改. 这表明网络的不稳定性有助于使信仰适应环境变化.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 计算神经科学是一种神经科学.
背景情况:
- 中间前额叶皮层 (mPFC) 参与处理关于世界的信念.
- 控制信念形成和修改的电路动力学仍然不太了解.
研究的目的:
- 为了研究神经电路动力学,根据环境变化对信念的修改做出反应.
- 在信念更新过程中将与内部状态相关的神经活动与行为方面分离.
主要方法:
- 在老鼠中利用一种新的任务来将内部状态编码与行为编码分开.
- 在中部前额叶皮质 (mPFC) 中记录神经活动.
- 分析了神经活动波动的变化和协调的神经激发模式.
主要成果:
- 在mPFC活动波动的暂时增加与环境变化后的信念修改相关.
- 大多数采样的神经元在放弃以前的信念进行探索时,表现出突然的,协调的活动变化.
- 观察到的网络切换到不稳定的状态,在探索过程中形成新的表示时稳定.
结论:
- 在mPFC中,网络的不稳定性对于在环境环境发生变化时修改信念至关重要.
- 这些发现阐明了支持信念更新和认知灵活性的动态神经机制.
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