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用于siRNA传递和成像应用的等级组装的theranostic纳米结构

Ritu Shrestha1, Mahmoud Elsabahy, Hannah Luehmann

  • 1Department of Chemistry, and Laboratory for Synthetic-Biologic Interactions, Texas A&M University, P.O. Box 30012, College Station, Texas 77842, USA.

Journal of the American Chemical Society
|October 12, 2012
PubMed
概括

新型的双功能纳米结构将静电治疗性货物输送与共价放射性标记相结合,用于增强光学. 这些等级组件在细胞转移和成像剂复杂化方面表现优于单个组件.

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...