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呼吁进行透明的报告,以优化临床前研究的预测价值

Story C Landis¹, Susan G Amara, Khusru Asadullah

¹National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA.

|October 13, 2012

概括

改善动物研究的方法报告至关重要. 关键建议包括详细说明样本大小估计,随机化,盲目化和数据处理,以提高科学严谨性.

科学领域:

神经科学是一个神经科学.
生物医学研究生物医学研究
动物模型动物模型

背景情况:

动物研究中的方法报告往往缺乏必要的细节.
不一致的报告阻碍了研究结果的可复制性和有效性.
美国国家神经疾病和中风研究所发现需要改进标准.

研究的目的:

讨论和建议改善动物研究的方法报告.
建立关于赠款申请和出版物的最低报告标准.
提高临床前研究的严谨性和可重复性.

主要方法:

在2012年6月召开了一场与主要利益相关方的研讨会.
讨论了研究设计和数据报告的关键要素.
为提高方法透明度制定了建议.

主要成果:

关键建议包括报告样本大小估计.
报告的基本要素是随机化方法和盲目的程序.
适当的数据处理协议也对研究完整性至关重要.

结论:

改善动物研究报告需要研究人员,审稿人,资助机构和出版商的共同努力.
实施这些报告标准将提高对严格研究设计的认识.
加强报告实践对于加速科学进步和确保可靠的研究成果至关重要.

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