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Updated: May 17, 2026

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在生物直角循环添加中相互正交的控制和设计

Yong Liang1, Joel L Mackey, Steven A Lopez

  • 1Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.

Journal of the American Chemical Society
|October 16, 2012
PubMed
概括

生物直角化学利用特定的反应,如阿齐德-二子环氧氨基酸和跨环氧氨基酸-四氨酸循环添加. 这些反应表现出非凡的选择性,使得新的试剂发现为精确的分子标记.

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Thermal cycloadditions are reactions where the source of activation energy needed to initiate the reaction is provided in the form of heat. A typical example of a thermally-allowed cycloaddition is the Diels–Alder reaction, which is a [4 + 2] cycloaddition. In contrast, a [2 + 2] cycloaddition is thermally forbidden.
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Some cycloaddition reactions are activated by heat, while others are initiated by light. For example, a [2 + 2] cycloaddition between two ethylene molecules occurs only in the presence of light. It is photochemically allowed but thermally forbidden.
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