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相关概念视频

Epistasis01:39

Epistasis

37.3K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
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Genetics of Speciation02:16

Genetics of Speciation

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Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
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Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
6.2K
Epistasis Analysis01:09

Epistasis Analysis

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Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
4.9K
Evolutionary Processes in Microbes01:26

Evolutionary Processes in Microbes

202
Microbial evolution occurs rapidly due to short generation times and a variety of genetic processes, including horizontal gene transfer, mutation, recombination, and genetic drift. These mechanisms collectively enable microbes to adapt swiftly to changing environments.Horizontal gene transfer (HGT) allows genes to move between different species and occurs through three main mechanisms: conjugation, transformation, and transduction. Conjugation involves direct cell-to-cell contact for DNA...
202
Evolution of New Traits in Microbes01:24

Evolution of New Traits in Microbes

199
Microorganisms evolve rapidly due to their large population sizes and short generation times, often exhibiting measurable changes within days under laboratory conditions. Natural selection acts on standing genetic variation, enabling the retention and amplification of beneficial traits that confer fitness advantages in changing environments.Adaptive Pigment Regulation in RhodobacterIn Rhodobacter, a genus of purple non-sulfur bacteria, light-harvesting pigments such as bacteriochlorophyll and...
199

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相关实验视频

Updated: May 5, 2026

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
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作为分子进化的主要因素的表现.

Michael S Breen1, Carsten Kemena, Peter K Vlasov

  • 1Bioinformatics and Genomics Programme, Centre for Genomic Regulation and Universitat Pompeu Fabra, 88 Dr Aiguader, Barcelona 08003, Spain.

Nature
|October 16, 2012
PubMed
概括

基因突变在不同的遗传背景中具有不同影响的表观性,在蛋白质进化中是普遍存在的. 大多数氨基酸替代只对特定物种有益,对长期的分子进化产生重大影响.

科学领域:

  • 分子进化分子进化
  • 遗传学 是一个遗传学.
  • 生物化学 生物化学

背景情况:

  • 长期分子进化的主要驱动因素尚未完全理解.
  • 阳性选择会影响氨基酸替代,但表观的作用尚不清楚.

研究的目的:

  • 量化估计长期蛋白质进化中的表皮病的发生率.
  • 将氨基酸使用数据与短期进化速率联系起来.

主要方法:

  • 对16个有机细胞和核编码蛋白质 (每个≥1,000个正义蛋白) 的多重序列对齐的分析.
  • 观察到的氨基酸替代率与在没有表观症的情况下预测的速率的比较.

主要成果:

  • 一个平均的蛋白位包含大约八种不同的氨基酸.
  • 测量的氨基酸替代率比中性进化率低20倍.
  • 大约90%的氨基酸替代是上下文依赖的,只有在特定的遗传背景下是中性的或有益的.

结论:

  • 表观是蛋白质进化的普遍力量.
  • 大多数氨基酸替代物在物种中表现出上下文依赖的适应性效应.
  • 经验对于理解长期蛋白质进化的节奏和模式至关重要.

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