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在腹部 tegmental 区域的奖励和厌恶的输入特定控制
Stephan Lammel1, Byung Kook Lim, Chen Ran
1Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, California 94305, USA.
Nature
|October 16, 2012
概括
截然不同的腹膜区域 (VTA) 电路产生奖励和厌恶. 来自后背体和侧面体的输入差异调节VTA多巴胺神经元,影响有动机的行为.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
背景情况:
- 腹部体区域 (VTA) 的多巴胺神经元对于奖励和动机至关重要.
- VTA亚群的具体作用及其在不同的动机循环中的投入仍然不清楚.
研究的目的:
- 为了调查不同的VTA多巴胺神经元亚群是否编码不同的动机状态.
- 为了确定VTA输入如何差异调节这些电路.
主要方法:
- 利用突触连接的差异来区分小鼠中的VTA电路.
- 检查了从后背侧体和侧面骨中激活输入的效果.
主要成果:
- 激活后背侧面 tegmental 输入引发奖励,而侧面 habenula 输入引发厌恶.
- 后背顶层神经元准VTA多巴胺神经元,这些神经元投射到核 accumbens 侧面外.
- 侧面大脑神经元准VTA多巴胺神经元,投射到中部前额叶皮质和侧向中部顶层细胞核.
结论:
- 确定不同的VTA电路会产生奖励和厌恶.
- 为理解动机行为的电路基础提供了一个新的框架.
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