针对冠状动脉疾病中的铁酸化表位体的免疫球蛋白
Leonor Thomson1, Margarita Tenopoulou, Richard Lightfoot
1Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104-4318, USA.
Circulation
|October 20, 2012
概括
对化蛋白的免疫反应与冠状动脉疾病 (CAD) 有关. 这项研究发现,在CAD患者中,对3-尼托铁素的抗体水平较高,这表明免疫反应在动脉样硬化中起着作用.
科学领域:
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
- 生物化学 生物化学
背景情况:
- 有证据表明免疫力在动脉样硬化中起作用.
- 氨酸化蛋白质在动脉样硬化病变和冠状动脉疾病 (CAD) 患者中被发现.
- 在动脉样硬化中,对酸蛋白的免疫反应尚不清楚.
研究的目的:
- 调查已确定的CAD患者对化蛋白的免疫反应的存在和重要性.
- 探索对3-甲氨酸的循环抗体与CAD的存在和严重程度之间的联系.
主要方法:
- 量化循环免疫球蛋白向患有CAD的患者的3 - 尼托铁胺表位 (n=374) 和非CAD对照 (n=313).
- 评估了免疫球蛋白水平与显著CAD的血管学证据之间的关联.
主要成果:
- 在人类动脉样硬化病变和血液循环中检测到识别3 - 尼托铁的特定免疫球蛋白.
- 与对照人群相比,患有CAD的患者对与蛋白质结合的3-尼托铁素的循环免疫球蛋白的平均水平高出10倍.
- 免疫球蛋白水平升高与血管学发现显著的CAD有很强的相关性.
结论:
- 在动脉样硬化动脉和血液循环中通过化对蛋白质的翻译后修改会产生新表位.
- 这些新表位物可以引起免疫球蛋白反应,将氧化剂生产与CAD中的免疫系统激活联系起来.
- 这项研究表明,在CAD的发病过程中,免疫系统激活和氧化剂产生之间存在联系.
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