具有pH响应的生物活性甘油聚,具有增强的螺旋性和水溶液中的溶解性
Kai-Steffen Krannig1, Helmut Schlaad
1Department of Colloid Chemistry, Max Planck Institute of Colloids and Interfaces, Research Campus Golm, Potsdam, Germany.
Journal of the American Chemical Society
|October 30, 2012
概括
新型葡萄糖多聚呈现出增强的稳定性和选择性结合. 这些葡萄糖改性聚合物表现出pH值依赖的结构,并与植物学菌素进行特定相互作用,为生物材料应用开辟了道路.
科学领域:
- 聚合物化学 聚合物化学
- 生物材料科学 生物材料科学
- 生物结合化学 生物结合化学
背景情况:
- 共聚具有可调节的特性,可用于先进的应用.
- 引入碳水化合物部分可以调节多的行为.
- 功能性多的受控合成仍然是一个关键的挑战.
研究的目的:
- 合成具有受控结构的新型葡萄糖多聚.
- 为了研究葡萄糖结合对多形状和稳定性的影响.
- 探索这些葡萄糖多聚与莱克的结合相互作用.
主要方法:
- 用于聚酸骨干合成的环开放聚合.
- 硫乙烯/烯光化学用于轻度葡萄糖结合.
- 循环二重化谱法用于分析二次结构.
- 用于莱克结合研究的度测定.
主要成果:
- 成功合成了L-glutamate和葡萄糖化L-/DL-allyl-或DL-propargylglycine的共聚.
- 葡萄糖化和非葡萄糖化多呈现了pH依赖的形状变化 (随机卷轴到α螺旋).
- 葡萄糖多聚胺在酸性pH (降至3.5) 时表现出增强的螺旋稳定性和可溶性.
- 证实了葡萄糖多聚类与康卡纳瓦林A的选择性结合.
结论:
- 温和的水性合成使得葡萄糖能够有效地引入多中.
- 葡萄糖结合显著改善了螺旋稳定性和可溶性.
- 开发的葡萄糖多聚表现出与植物学菌素的特定相互作用,这表明生物传感或药物输送的潜力.
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