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在抗体缺乏的小鼠中,内源性逆转录病毒的复活

George R Young¹, Urszula Eksmond, Rosalba Salcedo

¹Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.

|October 30, 2012

概括

在小鼠的免疫缺陷允许内源逆转录病毒 (ERVs) 激活,导致疾病. 减少肠道微生物阻止了ERV激活,这表明免疫力,微生物和ERV相关的疾病,如癌症之间的联系.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
遗传学是一个遗传学.

背景情况:

哺乳动物宿主拥有复杂的微生物组和内源逆转录病毒 (ERV),是基因组的组成部分.
主体,微生物和ERV之间的相互作用具有复杂的,往往不清楚的长期后果.
鼠标菌株C57BL/6 (B6) 缺乏能够在小鼠细胞中复制的内源性小鼠白血病病毒 (MLV).

研究的目的:

在C57BL/6小鼠模型中调查内源逆转录病毒 (ERV) 的控制.
了解免疫状态和微生物存在在ERV激活和病原发生中的作用.

主要方法:

在C57BL/6小鼠中研究了ERV控制,这些小鼠有各种影响抗体产生的免疫缺陷.
评估了养殖条件,特别是肠道微生物群水平对ERV激活的影响.
监测传染性生态热带性MLV的出现和传播以及随后的淋巴瘤的发展.

主要成果:

在免疫缺陷B6的小鼠中,完全传染性的生态热带MLV自发地出现.
再组合逆转录病毒感染了小鼠群落,导致逆转录病毒诱导的淋巴瘤.
在没有或减少肠道微生物群的小鼠中,无论免疫状况如何,都防止了ERV激活.

结论:

免疫力在控制内源逆转录病毒 (ERVs) 方面发挥着至关重要的,以前不被重视的作用.
微生物触发物,免疫激活和与ERV相关的病理,包括癌症之间存在机械联系.
肠道微生物群状况是预防免疫缺陷宿主中ERV激活的关键因素.

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