调解器头模块的结构
Laurent Larivière1, Clemens Plaschka, Martin Seizl
1Gene Center and Department of Biochemistry, Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25, 81377 Munich, Germany. larivier@genzentrum.lmu.de
Nature
|November 6, 2012
概括
调解器的头部模块中介者.
科学领域:
- 分子生物学分子生物学
- 结构生物学是结构生物学.
- 生物化学 生物化学
背景情况:
- 调解者复合体对于RNA聚合酶II的基因转录至关重要.
- 它将转录调节器与RNA聚合酶II联系在一起,并与人类疾病有关.
- 由保存的子单元组成的调解器头模块是这个复合体的关键组成部分.
研究的目的:
- 为了确定从Schizosaccharomyces pombe.中介体头模块的de novo晶体结构.
- 为裂变酵母媒介头模块提供详细的建筑模型.
- 阐明调解器功能的结构基础及其在基因调节中的相互作用.
主要方法:
- 在3.4 Å分辨率的X射线晶体学.
- 一个新的结构确定.
- 现有和新确定的子单位结构的整合.
主要成果:
- 确定了Schizosaccharomyces pombe Mediator头部模块的晶体结构.
- 揭示了一个鱼头样结构,有八个不同的,部分移动的元素.
- 确定了关键领域,包括固定下巴 (牙和鼻子) 和部 (螺旋式脊柱,肢体与肩膀,手臂,手指).
- 结构表明灵活性和保护,对与RNA聚合酶II的相互作用有影响.
结论:
- 确定的结构为Saccharomyces cerevisiae Mediator头部模块提供了一个修订后的模型.
- 突出介质头部模块内的高节约性和固有的灵活性.
- 提供了对影响调解器功能的突变的见解,并为了解基因调节机制提供了一个框架.
相关概念视频
Integrator and Differentiator
Op-amp circuits have significant applications in various fields, including automotive engineering. One such application is cruise control systems in cars, where op-amp circuits are integral for maintaining a constant speed. In these systems, op-amps function as both integrators and differentiators.
An integrator within an op-amp circuit produces an output directly proportional to the integral of the input signal. This is achieved by replacing the feedback resistor in a typical inverting...
An integrator within an op-amp circuit produces an output directly proportional to the integral of the input signal. This is achieved by replacing the feedback resistor in a typical inverting...
Mesh Analysis for AC Circuits
In the domain of radio communication, the significance of impedance matching must be considered. It is crucial to ensure the efficient transmission of signals between radio transmitters and receivers. Achieving this balance involves using impedance-matching circuits, with one fundamental configuration comprising a resistor, capacitor, and inductor.
The process of harmonizing these impedances begins with a clear understanding of the input and output signals. Once these signals are known, the...
The process of harmonizing these impedances begins with a clear understanding of the input and output signals. Once these signals are known, the...
Source Transformation for AC Circuits
The process of source transformation in the frequency domain entails the conversion of a voltage source, positioned in series with an impedance, into a current source that is parallel to an impedance, or the other way around. It is essential to maintain the following relationships while transitioning from one source type to another.
Bridge rectifier
The bridge rectifier is essential in electronics for efficiently converting alternating current (AC) to direct current (DC). Comprised of four diodes configured in a bridge layout, this rectifier effectively processes both the positive and negative halves of the AC waveform, making it superior to half-wave and full-wave center-tapped rectifiers in terms of voltage regulation and output stability.
Operationally, the bridge rectifier allows current flow through two of its diodes during each...
Operationally, the bridge rectifier allows current flow through two of its diodes during each...
Block Diagram Reduction
The process of deriving the transfer function of a control system often involves reducing its block diagram to a single block. This simplification can be achieved through a series of strategic operations, including relocating branch points and comparators. These operations preserve the overall function of the system while allowing for easier manipulation and combination of blocks.
The first step in this process is the identification and relocation of a branch point. A branch point, where a...
The first step in this process is the identification and relocation of a branch point. A branch point, where a...
Bus Impedance Matrix
Calculating subtransient fault currents for three-phase faults in an N-bus power system involves using the positive-sequence network. When a three-phase short circuit occurs at a specific bus, the analysis uses the superposition method to evaluate two separate circuits.
In the first circuit, all machine voltage sources are short-circuited, leaving only the prefault voltage source at the fault location. The positive-sequence bus impedance matrix can be determined by solving the nodal equations,...
In the first circuit, all machine voltage sources are short-circuited, leaving only the prefault voltage source at the fault location. The positive-sequence bus impedance matrix can be determined by solving the nodal equations,...


